HTN Initially 6.25 mg bid for 7-14 days, then increase to 12.5 mg bid. May further increase, if necessary, at intervals of at least 2 wk, to 50 mg once daily or in divided doses.
Elderly 12.5 mg once daily.
Heart failure Initially 3.125 mg bid. If tolerated, increase after 2 wk to 6.25 mg bid. Gradually increase at intervals of not <2 wk to max dose.
Patient w/ mild to moderate heart failure weighing >85 kg Max dose: 50 mg bid,
severe heart failure or weighing <85 kg Max dose: 25 mg bid.
Angina pectoris Initially 12.5 mg bid. Increase after 2 days to 25 mg bid.
Left ventricular dysfunction following MI Initially 6.25 mg bid. If tolerated, increase after 3-10 days to 12.5 mg bid & then to a target dose of 25 mg bid.
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